Season 5 (Supergirl)

​​​​​​ was renewed for a fifth season by The CW on January 31, 2019. It premiered on October 6, 2019, and will consist of 22 episodes.

Main cast

 * Melissa Benoist as Kara Danvers/Supergirl
 * Mehcad Brooks as James Olsen/Guardian
 * Chyler Leigh as Dr./Director Alex Danvers
 * Katie McGrath as Lena Luthor
 * Jesse Rath as Querl Dox/Brainiac 5
 * Nicole Maines as Nia Nal/Dreamer
 * Azie Tesfai as Dr. Kelly Olsen
 * Andrea Brooks as Eve Teschmacher and Hope
 * Julie Gonzalo as Andrea Rojas/Acrata
 * Staz Nair as William Dey
 * David Harewood as J'onn J'onzz/Martian Manhunter

Recurring cast

 * Jennifer Cheon Garcia as Midnight
 * Phil LaMarr as Malefic J'onzz
 * Ellexis Wejr as Mallory
 * Jeremy Jordan as Winn Schott
 * Meaghan Rath as Brainiac 5
 * Cara Buono as Gamemnae
 * Mitch Pileggi as Rama Khan
 * LaMonica Garrett as Mar Novu/The Monitor and the Anti-Monitor
 * Kari Wahlgren as Hope (voice)

Confirmed plot points

 * Jesse Rath's sister, Meaghan Rath, will appear as a female Brainiac 5.
 * Lex Luthor is coming back.

Confirmed characters

 * Gamemnae: An ancient alien, who with others of her kind, has been safeguarding the Earth from the follies of humanity throughout the ages. Gamemnae aims to use technology to subjugate humans. Gamemnae is cunning, witty, ruthless, and always ten steps ahead of her adversaries. Gamemnae’s agenda puts her into conflict with her would-be allies and on a collision course with Supergirl.
 * Rama Khan: An ancient alien who can control the four ancient elements — fire, water, earth, and air. Arrogant and willful, Rama Khan has been entrusted to use his powers to protect the Earth from mankind for millions of years but now his agenda puts him at odds with Supergirl as well as Lena Luthor.
 * Anti-Monitor