Board Thread:Council of Arrowverse Wiki/@comment-9346948-20180119051714/@comment-1783334-20180123234700

No, the only thing worth mentioning about that is on magic's own page staying a practitioner skilled enough with Magic can wield it with enough power to harm a Kryptonian.

Cold guns have a unique effect on speedsters, like Kryptonite. It essentially slows their superfast metabolism to a crawl and negates their powers, much like how Kryptonite affects Kryptonians.