Season 5 (Supergirl)

​​​​​​ was renewed for a fifth season by The CW on January 31, 2019. It premiered on October 6, 2019, and will consist of 22 episodes.

Main cast

 * Melissa Benoist as Kara Danvers/Supergirl
 * Mehcad Brooks as James Olsen/Guardian
 * Chyler Leigh as Dr./Director Alex Danvers
 * Katie McGrath as Lena Luthor and Lena Luthor's mother
 * Jesse Rath as Querl Dox/Brainiac 5
 * Nicole Maines as Nia Nal/Dreamer
 * Azie Tesfai as Dr. Kelly Olsen
 * Andrea Brooks as Eve Teschmacher and Hope
 * Julie Gonzalo as Andrea Rojas/Acrata
 * Staz Nair as William Dey
 * LaMonica Garrett asMar Novu/The Monitor and Mobius/Anti-Monitor (voice)
 * David Harewood as J'onn J'onzz/Martian Manhunter

Recurring cast

 * Phil LaMarr as Malefic J'onzz
 * Ellexis Wejr as Mallory
 * Kari Wahlgren as Hope (voice)
 * Nick Sagar as Russell Rogers/Rip Roar
 * Cara Buono as Gamemnae
 * Mitch Pileggi as Rama Khan
 * Jeremy Jordan as Winn Schott
 * Meaghan Rath as Brainiac 5
 * Thomas Lennon as Mxyzptlk

Confirmed plot points

 * Jesse Rath's sister, Meaghan Rath, will appear as a female Brainiac 5.
 * Mxyzptlk will return, however, it will be played by Thomas Lennon instead.

Trivia

 * Mehcad Brooks and LaMonica Garrett are only credited for their respective episode appearances.