User blog comment:Xandermcc/Lena the Villain?/@comment-32870856-20180205073636

Well, Lena in Post-Flashpoint continuity was the highly-intelligent sister of Lex, same as on the show. She became disabled after Lex, despite knowing that he could have stopped her being disabled, didn't prevent for fear of failure. Lena ends up disabled, and Lex carries the guilt of failure-by-inaction for the rest of his life.

Later in the Darkseid War, Lena shoots Lex, but falls unconcious. At the start of Rebirth, in the Superwoman title (with Lana Lang as Superwoman), Lena, sick of being under Lex's shadow and hating how he let her lose the use of her legs when he could have prevented it, loses it, creating Bizarro clones of the original Superwoman (Lois Lane from Earth 3), stealing a mother box from Lex and creating War suit that looks like Lex's, but far more advanced and bigger. She even created a failsafe that if she perished (revealed later), an Artificial Intelligence called Midnight would go after Superwoman (Lana Lang), drain her energy, and revive Lena. It, however, failed.

So, it would appear that Lena's across the multiverse don't take betrayal very well. The above was just an example of what Lena Luthor could be capable of.