The building where John and Ritchie have a conversation is called Bradstreet Hall. It is named for Tim Bradstreet, a comic book artist that did artwork for the comic Hellblazer. This episode features three actors who have all appeared as recurring characters on Lost - Harold Perrineau, Jeremy Davies, and William Mapother.
Oglethorpe University in Atlanta is the actual campus used as Ivy University in this episode.
Ritchie talks about the concept of the singularity and a human soul merging with a computer in order to live on. In the graphic novels, Ritchie's essence ultimately ends up trapped within a computer and the overall web of computer connections.