BTHK Biotech original intended to create the compound for the purposes of being a powerful antibiotic. However, the result was a super-virus, which came to be known as the"Alpha".
In 2009, the Hong Kong military was in possession of the virus, before General Matthew Shrieve acquired it for the United States.
Eventually, Shrieve combined the Alpha and Omega to create the Alpha-Omega virus, which he then planned to release on Hong Kong. The plan was successful but Shrieve was killed by Oliver Queen and Maseo Yamashiro.