- "This is where we came up with the cerebral inhibitor to use against DeVoe."
- —Savitar on the attack on Clifford DeVoe using the inhibitor.[src]
After Cecile Horton complained about hearing Joe West's mind all night, Harrison Wells created a device to disrupt inbound brainwave broadcasts. However, the initial device was too large and Harry Wells reconfigured it to a smaller version. When Harry presented it, the two decide they should reverse the polarity so outbound brainwave broadcasts are disrupted.
Harry later presented the device to Team Flash to use against Clifford DeVoe. While it appeared to affect him, DeVoe used Kilg%re's abilities to nullify the device, rendering it ineffective against him.
After Caitlin's Killer Frost side resurfaced, after she had seemingly lost Killer Frost in a battle against DeVoe, Caitlin began using the cerebral inhibitor to bypass the mental blockage he placed in her mind to talk with Killer Frost. After a week of using the inhibitor, Caitlin and Killer Frost were able to talk and switch identities without the use of the device.
When Nora West-Allen was stuck in Grace Gibbons' mind, and Barry and Iris were stuck in Nora's, Caitlin used the inhibitor to communicate with them before the device began smoking, forcing her to stop.
- Disrupting brainwave broadcasts: Although initially built to disrupt inbound brainwave broadcasts, the polarity was reversed to disrupt outbound brainwave activity.
- Thought reading: With the use of a secondary device, the cerebral inhibitor can be used to hear the thoughts of another person.