The Culebras have a long-standing rivalry with the Los Halcones. The organization gets their military-grade weapons from the Bratva.
In 2008, the Culebras ran the Glades, often clashing with vigilantesTed Grant and Isaac Stanzler. At some point, Isaac beat a Culebra drug dealer to death with brass knuckles. The gang then captured and tortured Isaac for months as retaliation, until he managed to escape.
In early 2011, the Culebras had a shootout with an SCPD S.W.A.T. unit, who were called to the edge of their territory in The Glades by a rival gang under the guise of a bomb alert.