"I have entered into people's minds using this very technology. From the unfortunate comatose victims of the Summerholt Institute to, yes, Jervis Tetch himself, the Terrible Mad Hatter Killer from Earth-221."
Harrison Sherloque Wells[src]

Earth-221 was one of the many universes in the original multiverse. It was the home universe of Harrison Sherloque Wells.


Sherloque sent Renee Adler to Earth-221 to keep her safe from Cicada.[1]

After Cicada was defeated on Earth-1, Sherloque decided to return home. He went to CC Jitters to get a drink, then noticed the door opening all by itself. Realizing that it was opening due to the meta-human Renee Adler, he smiled.[2]

In 2019, Earth-221 was destroyed by antimatter during the Anti-Monitor Crisis.

Known individuals



From Earth-1

Known locations


The Flash

Season 5

Season 6


  • Sherloque implied that Thanksgiving doesn't exist on this Earth.[4]
  • According to Sherloque, there are no Zambonis present on Earth-221. During the winter, ice is cleared manually with squeegees. Winter also lasts for eight months of the year.[3]
    • This explains Sherloque stating, "I thought your Earth would be colder" along with the overcoat he initially wore upon arriving on Earth-1.[5]

Behind the scenes

  • Earth-221's designation is most likely a reference to 221B Baker Street, the London address of the fictional detective Sherlock Holmes.


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