After the S.T.A.R. Labs particle accelerator exploded, Eobard acted crippled and began using the wheelchair. He used it to eliminate any consideration of him being the Reverse-Flash and for sympathy, as well as to charge his super speed.
After Eobard was erased from existence when his ancestor Eddie killed himself, the team stowed away the wheelchair. The parts used to charge Thawne's speed were used as parts to the Power Cane, a device employed to stabilize the condition of Martin Stein during the search for a second Firestorm.
After Zoom damaged Barry's spine, he used the wheelchair until he could walk again.
During Earth X's New Reich's attempt to invade Earth-One, Thawne briefly used the wheelchair, mainly due to his sentiment that he had built S.T.A.R. Labs and ran it for 15 years.
- Eobard Thawne (stopped using it after his true identity was discovered)
- Hannibal Bates (briefly lent to Hannibal Bates when Eobard had him pretend to be him)
- Barry Allen (after Zoom damaged Barry's spine, Barry used the wheelchair until he could walk again)
The Flash: Season Zero
- Eobard prepared to get out of it distinctively twice when he was still using it, once when he almost stepped out of it to save Barry, and a second time when he almost sped out of it when a robotic bee almost stung him.