- "I've seen firsthand how that kind of anger can tear a family apart. I've lived that heartbreak. And I wanna make sure nobody else has to. If humans and aliens can just listen to each other, then we can stand up, united, against those who seek to divide us."
- —George Lockwood[src]
Following his father's footsteps
George and the rest of his family all suffered in some way or another through alien incidents. George's father led the Children of Liberty and was arrested for multiple criminal acts against aliens. While his father was in prison, George joined the Children of Liberty and continued his work until Ben was released and made United States Secretary of Alien Affairs.
After Ben began his new job, George followed his father to Washington, D.C., where Ben gave him a tour of the place and even took him along when he went to see Senator Granberry about the Alien Amnesty Act. When the two returned to National City, after seeing the Children of Liberty take an alien mother from her home and kids, George lost the taste for the work they were doing. When he asked his father about it, Ben assured him of the importance of their work and asked his first in command in the Children of Liberty to take George along on their raids.
George was with Ben, as he oversaw an arrest of an innocent alien. He felt uncomfortable about it. Ben left him with one of his lieutenants so that he would learn the "necessity" of what they are doing. He joined in a raid to Al's Dive Bar, where he discovered that one of his friends, Charlie, was an alien. The raid was stopped by Dreamer, and George went home. There, he became more disillusioned, when Lydia claimed it was necessary. Later in the steel mill, he took one of the Children of Liberty masks and threw it into a wall, severing his allegiance with them, and texted Charlie he will have a friend in him. Shortly after, an alien murdered his mother Lydia, in retaliation for Ben, as he had falsely imprisoned her husband. During the funeral, as George was giving his mother's eulogy, Ben left him to get the alien who killed Lydia, in an act of vengeance. When George confronted his father, Ben said he had no choice. Discovering that hate has consumed his father displeased and disillusioned George; with that, George decided not to have anything to do with his father anymore.
Shortly after, George's father, Ben was imprisoned when his connection to Lex Luthor's plans with the corrupt president Phil Baker, as well as his acts of domestic terrorism, were revealed. Much to his father's chagrin and disappointment, George gave a speech to the press. CatCo reporter, Nia Nal, asked him some questions, he assured her and the world that he will do all he can to turn back hatred, and help prevent it from tearing apart families like it did with his, as well as bring back honor to his family. Supergirl was present at George's press conference, smiling for George out of pride.
It is unknown, if George was one of the Earth-38 refugees during the Anti-Monitor Crisis. Whether he was or not, he was eventually killed, when the Anti-Monitor's wave of antimatter destroyed the multiverse, only to be restored a month later due to the Paragons and the Spectre creating a new multiverse.
George, in an alternate timeline created by Kara and Mxyzptlk, became a member of the Cult of Rao, along with his grandfather and mother. They killed each other in hopes that Supergirl would save them by jumping off a roof. As a result, his father, Ben became the leader of the Children of Liberty and not only forced Supergirl to reveal her identity, but also murdered everyone Kara cared about out of revenge for losing his George and the rest of his family.
Initially, George had an anti-view on all aliens in general (due to his grandfather, Peter Lockwood having a bad influence on him) however, after George discovered that one of his friends is an alien, he becomes disillusioned and disgusted with the Children of Liberty's crusade, and his parents, Ben and Lydia Lockwood's propaganda towards aliens respectively. He has also grown resentful towards his father, Ben for focusing more on his obsession with aliens than his own son, and for using his mother and grandfather's deaths as an excuse for his vengeance.
Initially, George look up to his father, Ben, believing that he started his crusade against aliens to protect the human race against alien threats, however, after his mother, Lydia was killed by a female alien who's husband was wrongfully arrested by the Children of Liberty, in retaliation for Ben's actions, he then realises that his father's crusade against aliens was out of selfishness, jealousy and hatred.
After which, George has lost complete trust, respect and love for his father, Ben; after realising that he cares for no one but himself.
George later become a peace activist, to put an end the hatred between humans and aliens alike; not only to restore honour back to the Lockwood family's name; which was tainted by Ben's actions, but to also to prevent what happened to his own family, from happening to other families as well; proving just how much George's opinion towards aliens has completely change, in a good way.
- George was likely taken in by relatives on his mother's side of the family; as there is no mention of his father having siblings.