- For his Earth-1 equivalent, see Harrison Wells (Earth-1).
- "You don't have to like me, I don't like you, but you have to work with me, to stop Zoom and Doctor Light. Can you do that?"
- —Harrison Wells to Cisco Ramon about trust[src]
In 1991, Harry founded S.T.A.R. Labsand is the father of Jesse Wells. He later held a press conference sometime after his particle accelerator exploded and created the metahumans to unveil a new series of gadgets and apps to alert the user of a metahuman presence and was confronted by The Flash and wanted him to expose his involvement in the Metahumans creation.  Sometime later, Harry happened upon a tour group of children walking through S.T.A.R. Laboratories and greeted them.
He found his way through a breach between Earth-2 and Earth-1, underneath Earth-1's S.T.A.R. Labs. Wells lurked around S.T.A.R. Labs for some time, watching Cisco Ramon in his efforts to save Martin Stein, then proceeding to make his way to Mercury Labs. As he stole a prototype weapon from the Applied Sciences Division, he set off the alarms but managed to evade the guards. He was however spotted by Tina McGee, an old friend of Harry's late Earth-1 counterpart, who mistook him for the murderer using Earth-1 Wells' appearance.
He later arrived in time to use the gun he stole on "King Shark", a metahuman sent by "Zoom", and knocked him out as he was attacking The Flash and Patty Spivot. As he walked away Flash chased after him and demanded to know who he was and Harry pulled his hood off, revealing his identity to him. 
Harry went to S.T.A.R. Labs where he met Cisco Ramon, Caitlin Snow, and Joe West, who were skeptical of him due to the actions of Eobard Thawne. The latter of whom tried to shoot him, only to have Barry catch the bullets. He then explained his intentions were to help them stop Zoom, who was influencing metahumans from Earth-2 to come to Earth-1 to kill Barry and then every speedster in the multiverse so he would be the only one. When another Earth-2 metahuman showed up, Dr. Light, later revealed to be Earth-2's Linda Park, they tried to convince her to stop and join them because she was a robber, not a killer. Harry however, opposed and wanted to capture her for information. He later revealed Cisco's secret, that he's a metahuman with the ability to see alternate timelines using a watch he used to detect the presence of nearby metahumans. Later after Dr. Light had killed Linda and Iris boss Eric Laken Harrison blamed Garrick for believing that someone under Zooms influence can be reasoned with and that he was the reason Barry doubted himself and eventually got into a fight with Jay, who he claimed had been running from Zoom for two years rather than the other way around and that unlike Garrick, Barry could stop and beat Zoom because he was not a coward and was willing to rush towards danger not from it. After Dr. Light was captured, he watched as Barry, Caitlin, and Cisco celebrated. In  Harry built a gun that would fire a dart that would dampen Zoom's speed once they lured him into the trap. Zoom however knew of the trap and Harry didn't get his chance to take down the demonic speedster. After Zoom brought an unconscious Barry Allen back to S.T.A.R labs after defeating him in battle, Zoom tells Harry that he made a mistake trying to use to the flash to stop him, which Harry admits. Zoom is shot with the dart by Cisco, but can still run at superspeed and escapes, upsetting Harry.
Unlike Eobard Thawne, Harry is very blunt and inconsiderate. He carries himself in a very sardonic, egotistical manner. For example, his reference to how Eobard killed Barry's mother is delivered in a casual and sarcastic manner, and he even straight up told Cisco he didn't like him in response to Cisco's initial wariness of Harry. He even laughed in amusement when Cisco told him Eobard killed him in an alternate timeline. He even bluntly told Jay that during the two years since he came the Flash of Earth-2, that he wasn't hunting or even fighting Zoom, but Zoom was hunting him. His harsh attitude, however, appears to be derived from a desperation to save his daughter who was kidnapped by Zoom, showing that he does indeed actually care quite a bit for others, especially those that are close to him.
- Genius-level intellect/Great business acumen/Master tactician: Harry is very intelligent, as he managed to run S.T.A.R. Labs very successfully for 24 years, since he founded his company. Harry is also a great tactician, he was able to come up with a plan to help Barry Allen defeat Dr. Light.
- Master engineer: Harry has proven to be a master in engineering as he was able to design a watch that can detect meta-humans.
- Hand-to-hand combatant: Harry has some experience in unarmed combat, as he was able to go head-on with Jay Garrick, yet the exact level of his fighting skills is unknown, as the fight was broken up by Barry.