Lois, Clark, and Natalie notice a difference in John Henry's behavior and fear something might be very wrong. Meanwhile, Kyle encounters an awkward moment with Lana while stopping by the house to pick Sarah up for school. Lastly, Jonathan and Jordan brace themselves when they realize a talking to from their parents is headed their way.[src]
In this episode, For Natalie Lane Irons, her time spent in the empty space between the two multiverses is said to have lasted "six months", according to her A.I. Hedy. However, over a year had passed since the Anti-Monitor Crisis by the time she arrived on Earth-TUD25 from the void. Because of the temporal irregularities for being outside of either multiverses' time-stream, Hedy's claim of Natalie being trapped for "six months" in the void is most likely inaccurate.
The antimatter wave that destroyed the Milky Way galaxy and headed towards Earth (Earth-TUD22), would need to travel trillions of times faster than light - to cover even half the distance across its 100,000 light-year diameter in a few seconds, nearing the Sun at the Solar System.
Out in space, the wave appears to sweep across the cosmos much more slowly or at subsonic speeds, where the two survivors of the Irons family could actually see the antimatter wave destroy the universe of Earth-TUD22 while Superman was chasing their spacecrafts:
The size of the anti-matter wormhole itself is inconsistent between the episodes "Through the Valley of Death" and "Into Oblivion"; the former episode features a portal that is 'only' the size of the cockpit of John Henry Irons' ship, where the spacecraft travelled through the tunnel and ended up atop a mountain on another Earth (Earth-TUD25), but the latter episode uses a wormhole that is more than enough to fit Natalie Lane Irons' ship; although the anti-matter wave itself consumed both the portal and the remaining universe of Earth-TUD22, leaving Natalie Lane Irons stranded in an empty void for months/as she floats in nothingness.