Irene Clayton is the wife of Frank Clayton, the mother of the late Samantha Clayton, and the grandmother of William Clayton.


At some point, possibly in the 1980s, she married Frank Clayton and gave birth to a daughter, Samantha.

In early 2019, after her grandson William returned to Star City, she and her husband, received a phone call from him where he apparently complained about his father. She and Frank decided to go to Star City and sue for guardianship of William. William ended up leaving with them and returning to Central City.[1]



Season 6

Season 7

Season 8


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