"I always wanted to be a hero, to use my extraordinary abilities to help people. That's why I came here. To meet my family, to stop Cicada, help fix the Flash's legacy, and save him from disappearing in the future. I believed I could do the impossible, but I never imagined it would turn out like this."
At the end of the episode, Ralph opens a case file marked with the name Dearborn. This is a reference to his wife in the comics, Sue Dibny, whose maiden name was Dearborn.
Thawne mentions that " this is the second time that I've been stuck somewhere for 15 years", a reference to Season 1 when he was stuck in the 21st century from 2000 to 2015.
Eobard splits himself in two, a reference to what Godspeed does in the comics as his signature move saying "God has the ability to be in all places at the same time", but in doing so his aspects become much weaker which is why Thawne pulls himself back.
Furthermore, in what is now an erased timeline, Barry also lost Iris after she'd been murdered by an evil future version of himself. In all of these instances, an evil speedster had been directly responsible for the death of a person Barry loves.
Nora being erased from existence was alluded in the Season 5 premiere, when Barry says that she could possibly "Marty McFly herself out of existence", referring to the protagonist of the 1985 film Back to the Future, who accidentally interferes with his parents' first meeting whilst traveling back in time, nearly erasing himself from existence.