- "The human race finally has a chance to live. Or it would suffer the same fate as Krypton."
- —Non on Myriad's intentions.[src]
Myriad was a technological program created by Astra to "force everyone to her way of thinking", turning them into mindless and obedient drones that could be directly piloted by the user or given verbal commands.
The neural signals from the program could be sent across an entire city through its computing and digital network, though it could not travel through older broadcasting technology. Maxwell Lord found that the signal worked by shutting down the parts of the brain that allow for optimism and hope, the amygdala and the rostral anterior cingulate cortex. At its highest frequency, it could cause headaches that build up into enough pressure inside the head of its subjects to cause it to burst, killing them.
Some aliens were unaffected by Myriad, such as Kara Danvers, J'onn J'onzz, Maxima, the White Martian, and the K'hund, while humans like Maxwell Lord and Cat Grant used "ion blocker" technology, designed to scramble Myriad's signal before it took effect in their minds. Alex Danvers managed to snap out of the program's control on her own will with coaxing from her mother, Eliza Danvers.
In response to the ecological disruption on Krypton, Astra first tried to use it on Argo City, which led to her and Non's incarceration in Fort Rozz. Krypton's High Council deemed the program as too dangerous to be discovered by other worlds, or from the planet's own citizens, due to its potential to upset the balance of power in the galaxy.
At night, though unseen, this program was put into effect on every citizen of National City by Non and Indigo. Every citizen of National City was put under Myriad's control, while Maxwell Lord and Cat Grant were protected by the former's ion blocker technology. Maxwell realized the Kryptonians were using his LTE interface system to broadcast it, which was why they attacked his facility. Superman was also affected by Myriad, which according to Maxwell, was due to the fact that Superman had been raised on Earth, thereby making his mind more human.
Kara, with the help of Maxwell and Cat, managed to broadcast a speech to the people of National City, inspiring hope in them to allow them to break free from Myriad's control.
Three years later, when Kara first brought Lena to the Fortress of Solitude and showed her the weapons that she and Clark confiscated from various enemies like Lex Luthor. Kara showed Lena Myriad and remarked on how it was the one thing she would destroy. After they defeated Leviathan's leader, Rama Khan, together, Lena attempted to take it, but Kara caught her. After a subsequent argument between the two former friends about trust, Lena used the fortress's security system against Kara and stole the device.
Lex Luthor wants to destroy the friendship of Lena and Kara Danvers so he uses Myriad to his advantage. Retaining memories from Earth-38, Lex has Querl Dox go to Kara Danvers and asks her to use Myriad to find the people kidnapped by Leviathan. At the same time, he convinces Lena that Project Non Nocere would be more effective with the Myriad program. He has Lena use his transmatter portal watch to get to the Fortress just as Supergirl is at the computer, causing Lena to view Supergirl as a hypocrite about who can use the program and why. The two argue about this, but before the program can be used, Lena leaves the Fortress and Supergirl fights a Morae who has released a sun-eater.
Lena uses Myriad to deprogram people that were made susceptible to Lex's program "I Love Lexi", where people are made to love and to be loyal to Lex. After Lex and Lillian were defeated, Lena used Myriad to erase Supergirl's secret identity from their minds. Alex Danvers reminded J'onn J'onzz that during the stopping of Myriad, he bonded with M'gann M'orzz so deeply, he literally had a piece of her soul.