- "Lex and Lena Luthor, teaming up to save Superman's best pal. What would Mother think?"
- —Lex Luthor to Lena Luthor
Secretly furloughed from prison due to failing health, Lex Luthor visits his sister, Lena, to seek her help finding a cure. Savvy as ever, Lena is suspicious of Lex's motives but when she’s faced with a life and death situation, she must decide how she truly feels about her brother. Meanwhile, Supergirl and J'onn face off against Manchester Black. James' sister Kelly comes to town.
- The episode's title is a reference to a fictional book of the same name in the 1941 film Sullivan's Travels.
- The title of this episode is from a Coens Brother 2000 film of the same name about the convicts who record a song in the depression era and become famous. The movie also draws a lot from the epic poem The Odyssey by Homer.
- In the flashback at the beginning, Lex turned the sun red in a bid to depower Superman, a reference to The War of the Superman storyline in 2010, when he briefly turned the sun red to save Earth from an invasion of hostile Kryptonians.
- Lex's act of creating an earthquake is a reference to the original Superman (1978), where Luthor's master plan was to use the quake to sink the west coast and turn the near-worthless desert real estate he'd bought up into a valuable water-front property.
- Lex having an inoperable cancer after injecting himself with Kryptonite is a reference to the original comics, where he discovered that Kryptonite radiation was deadly to humans (if not quite so fast-acting as it is with Kryptonians) after he began wearing a Kryptonite ring to keep Superman at bay and later developed cancer.
- Brainiac-5's contention that he usually gets along so well with machines may be a reference to his creation, in the DC comics, of COMPUTO, a sentient machine which became one of the greatest adversaries of the Legion of Super-Heroes.
- There's a factual error in Lex Luthors's citation. Epicurus lived between 341–270 BC - making his statement over 2000 years old instead of ~280.
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