- "And yes, there will always be extremists like whoever attacked the bar, but overall, I think this country has made incredible progress. The president is about to celebrate the second anniversary of the Alien Amnesty Act, and for the first time on Earth, aliens are embraced as citizens with equal rights."
- —Kara Danvers to J’onn J’onzz
Diving back into reporting, Kara welcomes a new cub reporter to CatCo. Meanwhile, James and Lena argue about James' impending indictment for acting as the vigilante Guardian, while Alex and Brainy struggle to get in sync at the D.E.O.. Supergirl is called into action when remnants of the anti-alien terrorist organization Cadmus try to assassinate pro-alien leaders, but their endgame turns out to be much more sinister than she expected. J'onn relishes his peaceful new life, but an outing with an old friend causes him concern.
- The episode's name is a reference to the limited comic book series Superman: American Alien by Max Landis.
- Lillian quips that her heart has "grown several sizes" in prison, to which Lena calls her "the Grinch Who Stole Christmas", referencing the protagonist of the Dr. Seuss book How the Grinch Stole Christmas!.
- Lillian mentions Bruno Mannheim as a former associate of Lex. In the comics, Bruno "Ugly" Mannheim was the leader of Intergang and an enemy of Superman.
- When Kara asks Nia why she didn't pinch her article idea to James, since it was better than the one pinched by Mackenzie, Nia says she was worried and that Mackenzie has more famous friends than Oprah, referring to the famous talk show host Oprah Winfrey.
- Lena claims to District Attorney Diaz that the new evidence against Bruno will put the latter behind bars for as long as Al Capone, a notorious American gangster who was sentenced to 11 years in prison for tax evasion.
- marks Vincent Gayle's second Arrowverse appearance. He previously played Pyotr Friedkin in the episode "".
- President Marsdin mentioned that former president Dwight D. Eisenhower named Camp David after his son and grandson, who were both named David. In real life though, the camp was actually named after Eisenhower's father and grandson; his sons were named Doud and John.
- However, it's possible the naming of the camp might be different in Earth-38's history.
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