DeVoe breaks the fourth wall by claiming that there will be no "defeating the big bad this year" to Barry, indirectly referring to his self-proclaimed superiority compared to the Reverse-Flash, Zoom, and Savitar in "Therefore I Am".
Ironically, this statement came true around the same time on Arrow, as Ricardo Diaz, who'd been the main enemy Oliver had been dealing with in Season 6 got away safely and didn't take long to return in Season 7, continuing to be a threat.
This is the first non-Supergirl episode in the Arrowverse that Kara Danvers is mentioned outside of crossovers, as Barry mentions Kara as a possible ally they could contact.
A cliffhanger which would have teased the villain for the next season was originally filmed for this episode. However, it was cut due to time constraints and the scene was used in the trailer for Season 5.